高龄中晚期肝癌经动脉药物灌注并栓塞治疗临床分析

Clinical analysis of advanced stage hepatic cancer elderly in combined therapy of arterial intervention and embolization

目的经导管脉动脉灌注化疗药物及栓塞作为晚期肝癌首选的姑息疗法，其临床价值已得到肯定。本文为探讨老年性肝癌采用此法的效果及开发症。方法已确诊的72例70岁以上老年性肝癌，采用经定肝动脉插管，成功后灌注化疗药物，一般为三联，后以碘化油乳化剂及明胶海绵碎屑沿导管注入，进行肝动脉栓塞。结果72例病人共进行介入治疗224例次。其中进行检室51例次，最多13例次，最小2例次，平均4．8例次。生存期最长18个月，最短4个月，平均生存6.5个月。CR7例，PR43例，NC17例，PDS例，总有效率（CR＋PR）为69．4％（50／72）。经治疗后患者肝区疼痛减轻、腹水明显消退，食欲增加，免疫指标提高。结论高龄中晚期肝癌采用肝动脉化疗药物灌注并栓塞米不失为一种有效的姑息疗法。

objective As the first choise of the palliative treatment for the advanced stage hepatic cancer, arterial intervention chemotherapy and embolization's clinical value is confirmed. This article vill discuss the curative effect and compliations of the therapy for hepatic cancer edlerly.Methods In the 72 cases of diagnosed hepatic cancer elderly(>70 years old),we did Percutluneous hepatic artery catherization, then ingested chemotherapy drugs which are triple in genaral, and then Nal emulsum and pieces of gelatin sponge into the duct to embolize the hepatic artery. Results: In the 72 cascs,there were patient inverventing 224 times, including 51 cases of embolization,maximum of 13 cases, minmum of 2 cases, average of 4. 8 cases. The longest survival period is more than 18 months,the shortest is 4 months,average is 6. 5 months. There were 7 cases with CR,43 cases with PR, 17 cases with NS, 5 cases with PD. Total effective rate was 69. 4% (50/72). With the heep of the therapy,patients said that the pain of hepatic region was alleviated, ascites disapeared obviously and the appetite became gnd. The indexes of immunity were incrased.Conclusion The therapy of hepatic arterial interventon and embolizotion of advanced hepatic cancer elderly was one of the most effective paliative treatment.