宫颈鳞状细胞癌患者血清鳞状细胞癌抗原变化的临床意义

Significance of squamous cell carcinoma antigen in squamous cell carcinoma of the uterine cervix.

目的 研究子宫颈鳞状细胞癌患者血清中鳞状细胞癌抗原水平与病理分级、临床分期及对治疗反应之间的关系。方法 利用雅培公司提供的 IMX全自动快速粒子酶免疫分析系统 ,对 2 5例正常献血员和 83例经病理学诊断的宫颈鳞状细胞癌患者 ,进行了血清中鳞状细胞癌抗原血清检测并分析其与病理分级、临床分期之间关系。其中 80例患者放射治疗前后血清鳞状细胞癌抗原水平变化情况进行了自身比较。结果 中晚期宫颈鳞状细胞癌患者血清鳞状细胞癌抗原水平与病理分级、临床分期之间无相关性。放射治疗前后患者血清鳞状细胞癌抗原水平有明显变化。结论 对子宫颈鳞状细胞癌患者 ,在治疗前后检测血清鳞状细胞癌抗原水平 ,可以作为对放射治疗疗效判断的参考指标之一。

Objective To investigate the association between squamous cell carcinoma of the uterine cervix and the antigen of squamous cell carcinoma in sera.Methods Eighty three patients with squamous cell carcinoma of the uterine cervix(FIGO Stage Ⅱ and Ⅲ) were evaluate the pretreatment level of squamous cell carcinoma antigen(SCCag).Results The pathologic pretreatment serum level of SCCag increased in cases with stage Ⅱ compared to that of stages Ⅲ(X±S=4.48±4.08,45.0% 9/20 versus X±S=6.58±2.78,66.67% 42/63).When the radiotherapy finished,the eighty patients were evaluated the posttreatment level of SCCag.The pathologic serum level of SCCag decreased significantly compared to that before the radiotherapy(X±S=6.26±2.39,60.0% (48/80) versus X±S=1.16±0.43,13.8% (11/80) (P<0 0005).Conclusion SCCag may increase greatly in recognizing the stage of squamous cell carcinoma of the uterine cervix and the different clinical response to the radiotherapy. [