陕西肺癌高发区宝鸡市肺癌危险因素研究

Risk factors of lung cancer in Shaanxi Baoji, a city with high lung cancer mortality: a case-control study

目的 探讨我国肺癌高发区之一陕西宝鸡市肺癌的危险因素。方法 采用病例 -对照研究。病例为宝鸡市 1 992～ 1 996年恶性肿瘤监测点登记的全部肺癌病人共 63例 ,按 1∶ 3比例配对选取 1 89例健康人为对照。共调查十类危险因素、78个问题。结果 单因素分析结果达到显著性水平的危险因素有吸烟、室内微环境污染、家庭经济状况、男性致癌物接触史 ;多因素分析结果基本一致。其中做饭取暖燃料种类 (液化气、蜂窝煤、烟煤 )、排气扇使用情况 (经常用、偶尔用、不用 ) ,年均收入存在明显趋势性 (趋势χ2检验 P <0 .0 5)。结论 除吸烟等其它因素外 ,宝鸡市肺癌与当地燃料种类及使用方式存在联系。

Objective To study the risk factors of lung cancer in Shaanxi Baoji where the lung cancer mortality rate was high.Methods A case control approach was conducted.Sixty three cases were all lung cancer patients registered during the period 1992 to 1996 in Baoji and 189 individually matched population-based controls were selected.Ten risk factors including 78 items were investigated.Results Results of single factor analysis showed that smoking,indoor air pollution, income of family,occupational exposures in males were related with lung cancer significantly (P<0.05).The results of multivariable analysis were similar to the results of single factor analysis.Risk of lung cancer increased with kinds of various fuels, ventilation condition,income of family, trends between these factors and lung cancer risk were found (Mantel Haenszel χ 2 test P<0.05).Conclusion In addition to smoking and some other factors, the kinds of fuel for cooking and warming and the way using fuel are very important risk factors of lung cancer in Baoji. [