摘要
本文将化学工程学原理应用于药物控制释放这一交叉学科,针对膜相扩散释放进行了动力学研究,建立、推导了“非稳态、有扩散边界层影响的释放动力学模型’,解决了现有模型“准稳态”假设产生的偏差,使模型更接近于实际释放过程.根据医疗科学和药物控制释放技术的发展趋势,设计了新颖的聚乙烯-乙烯醇/维生素B_(12)混合药膜释放体系.利用该体系验证了本文所建立的模型.
The principle of chemical engineering was applied to drug delivery. Am unsteady-state delivery kinetics model with boundary diffusion layer resistance was established to replace the 'Pseudosteady-state Assumption' which deviates from the real delivery process. A novel poly (ethylene-vinyl alcohol)/vitamin B12 slab delivery system was designed and used to verify the model. The results showed that the model was effective in describing and predicting the delivery behaviors for a diffusion-controlled polymer/drug release system.
出处
《化工学报》
EI
CAS
CSCD
北大核心
1991年第2期225-230,共6页
CIESC Journal
