几种稀土化合物对SMMC-7721人肝癌细胞的抑制效应

Inhibitory Effects of Several Kinds of Rare Earth Compound on SMMC-7721 Human Hepatoma Cells

取人肝癌细胞体外 37℃恒温培养 2 4小时 ,加入不同浓度的稀土化合物 :(C1 0 H1 0 N2 S) 3L a、(C1 0 H1 0N2 S) 3Nd、C1 9H1 8N4SL a、(C1 0 H1 0 N2 S) 3Na Sm Cl3,继续培养 36小时 ,用 0 .1%台盼蓝活体染色后进行细胞计数 ,通过细胞生长抑制率、半数抑制浓度考察了这几种化合物对人肝癌细胞的抑制效应。结果表明 :四种化合物对人肝癌细胞均具有明显的抑制作用 ,其中 (C1 0 H1 0 N2 S) 3L a、C1 9H1 8N4SL a效果明显好于 (C1 0 H1 0 N2 S) 3Nd、 (C1 0 H1 0N2 S) 3Na Sm Cl3;而 (C1 0 H1 0 N2 S) 3Nd又好于 (C1 0 H1 0 N2 S) 3Na Sm Cl3。

Different concentrations of rare earth compound of (C 10 H 10 N 2 S) 3La,(C 10 H 10 N 2 S) 3Nd,C 19 H 18 N 4 SLa,(C 10 H 10 N 2S) 3NaSmCl 3 were added into human hepatoma cells (SMMC 7721)that cultured for 24 hours in vitro.After incubating for 36 hours,the cells were dyed with typan blue.The effect of inhibition of these compounds was measured in term of the cell growth inhibiting rate and the halfinhibiting concentration of cells.The result shows that (C 10 H 10 N 2 S) 3La and C 19 H 18 N 4SLa can inhibit the cells effectivelier than (C 10 H 10 N 2 S) 3Nd and (C 10 H 10 N 2S) 3NaSmCl 3,while (C 10 H 10 N 2S) 3Nd can inhibit effectivelier than (C 10 H 10 N 2 S) 3NaSmCl 3.