一种新型气相色谱手性固定相的制备及应用

Preparation of a New GC Chiral Stationary Phase and Its Application

合成了一种新的手性固定相 ,2,6_二_O_三甲基硅烷基_3_O_乙酰基_β_环糊精 ,以甲基苯基硅油为稀释剂 ,成功地将其涂渍到弹性石英毛细管柱上 ,该手性柱具有柱效高、惰性好、热稳定性好等色谱性能 ,对几类对映体进行了拆分 。

A new chiral stationary phase, 2,6 _ di _ O _ trimethylsilyl _ 3 _ O _ acetyl _ β _ cyclodextrin, was synthesized, and coated on a fused silica capillary column with methyl _ phenylsilicone oil as a diluent. Chromatographic properties of the stationary phase were investigated, and satisfactory resolutions were achieved for most of the studied enantiomers. The experimental results show that the acetylated and silylated β _ cyclodextrin derivative is suitable for use as chiral stationary phase with good chromatographic properties such as high column efficiency, good thermal stability and inertness in separating enantiomers.