车间空气中奥克托今卫生标准研究

Study on the Health Standard of Octogen in the Air of Workplaces

目的 为了解奥克托今的危害程度及其发病情况 ,制订我国车间空气中奥克托今最高容许浓度(MAC)和时间加权平均容许浓度 (TWA)。方法 进行了奥克托今的毒理学研究、职业流行病学调查研究 ,并与其同系物黑索今进行了对比。结果 奥克托今对大鼠属实际无毒性物质 ,对小鼠有轻微毒性 ,奥克托今属中等蓄积性物质 ,无皮肤刺激作用 ,无致癌、致畸、致突变作用。动物实验及流行病学观察 ,其中毒症状主要表现为神经系统异常改变 ,重度者还出现肾小管变化或明显的肝脏中毒改变。奥克托今毒性远小于黑索今。结论 提出我国车间空气中奥克托今最高容许浓度建议值为 4mg/m3,时间加权平均容许浓度为 2mg/m3。

Objective\ The aim of this study is to investigate the occupational health risk level and the adverse effects of octogen,and to establish the maximum allowable concentration(MAC)and the time weighted average concentration(TWA)of octogen in the air of workplaces in this country.Methods\ Toxicological study and epidemiological investigation of octogen were conducted.The comparison between octogen and hexogen was made.Results Octogen may be considered practically non toxic in rats and slightly toxic in mice.It may also be consi\|dered a medium cumulative chemical.It has no irritant action to the skin.Its not carcinogenic,teratogenic or mutagenic.By animal experiment and epidemiological observation,toxic symptom of octogen was mainly the nervous system abnormality.The tubular kidney changes and significant toxic liver changes were observed in severe toxic animal experiment.The toxicity of octogen seemed lower than that of hexogen.Conclusions It is proposed that MAC for octogen in the air of workplaces in this country may be set as 4 mg/m 3 ,and its TWA 2 mg/m 3 。