血管性痴呆的治疗与电生理研究

The Investigation of Therapy and Electrophysiology on Vascular Dementia

目的:探讨毒扁豆碱对血管性痴呆(VD)的治疗效果。方法:以双盲对照方法,检测应用毒扁豆碱治疗的50例由于缺血性脑血管病所致的轻、中度VD,观察其疗效及治疗前后的电生理学改变。结果:毒扁豆碱对轻、中度VD的智能改善效果肯定,电生理指标也确有好转,服用过程中未见明显毒副作用。结论:毒扁豆碱能在一定程度上改善轻、中度VD病人的认知功能。

Objective:To investigate the curative effect of physostigmine on vascular dementia patients. Methods: Fifty patients with mild to moderate vascular dementia caused by ischemic cerebral vascular disease were treated by physostigmine, and the curative effect and the changes of electrophysiology before and after treatment were evaluated using double-blind contrast method. Results: Physostigmine achieved definite effect in improving intelligence in patients with mild and moderate cerebral vascular dementia. The result of electrophysiologic examination improved, and the side-effect was not recorded during the treatment. Conclusion: Physostigmine can improve the recognitive ability definitely in mild to moderate vascular dementia patients.