原发性肾上腺恶性淋巴瘤临床病理学研究(附二例报告及文献复习)

A clinico-pathological study of primary adrenal lymphoma(report of 2 cases)

目的 探讨原发性肾上腺恶性淋巴瘤的临床及病理学特点。 方法 分析 2例原发性肾上腺恶性淋巴瘤病例资料 ,并进行组织形态学观察和免疫组织化学检测。 结果 2例患者年龄分别为 45岁及 5 7岁 ,临床上无特异性 ,组织学上瘤细胞呈弥散分布 ,其间可见薄壁小血管 ,瘤细胞多呈圆形或卵圆形 ,胞浆少 ,核深染 ,异形明显 ,可见核分裂像。免疫组化染色LCA、L2 6、CD74 阳性 ,UCHL 1阴性 ,S 10 0蛋白及CK阴性。 2例病人中 1例术后 3个月因明显恶液质体征自动出院 ,1例失访。 结论 原发性肾上腺恶性淋巴瘤是一种罕见的、恶性程度较高的肿瘤 。

Objective To study the clinico pathological features of primary adrenal lymphoma (PAL). Methods 2 cases of PAL were reviewed and studied. Results The age of the 2 patients was 45 and 57.The presenting symptoms were nonspecific.Histologically,the neoplasm was composed of numerous medium sized cells with round nucleus,usually 1 2 in number and with relatively abundant basophilic cytoplasm.The neoplastic cells showed frequent mitosis.Immunohistochemically,the tumor cells were strongly positive for LCA,L26 and CD 74 while negative for UCHL 1,S 100 protein and CK. One case was discharged 3 months after operation because of dyscrasia and the other was lost on follow up.Prognosis of PAL was poor. Conclusions PAL is extremely rare with a high grade of malignancy.The diagnosis could be made on histopathological studies and immunohistochemical studies.