半夏泻心颗粒剂改善胃动力的实验研究

Experimental studies on improvement of gastric dynamic with granulater of Banxia xie xin

本实验以ｗｉｓｔａｒ大鼠和昆明种小白鼠为研究对象，观察“半夏泻心颗粒剂”对大鼠体表胃肌电ＡＰ值、 ＦＰ值以及大、小鼠胃排空率指标，用“酚红法”、“体表胃肌电法”实验并同时做了自身用药前后对比，生理盐水对照和吗丁啉治疗对照．结果“半夏泻心颗粒剂”１．８ｇ／ｋｇ，０．９ｇ／ｋｇ使大鼠体表胃肌电ＡＰ值提高３７．５％、８２．４％（Ｐ＜０．０１），ＦＰ值提高４３．３％、１８．３％．胃排空率，大鼠提高５４．２％（Ｐ＜０．０５），５４．９％（Ｐ＜０．０５）小鼠胃排空影响明显，与生理盐水组比较，９ｇ／ｋｇ组Ｐ＜０．０５，６ｇ／ｋｇ组Ｐ＜０．０１，３ｇ／ｋｇ组Ｐ＜０．０１，分别与吗丁啉组接近，结果提示“半夏泻心颗粒剂”有改善大鼠体表胃肌电，提高大、小鼠胃排空的作用．

In order to determine the effect of 'granulater of Ban xia xie xin (BXXX)' on gastric dynamic, rat gastro- electrogastrography and rats and mouses red phenal gastrexcretion test were done after administration. The result showed that The gastro-myoelectric AP value of rat body surface was increased by 37.5% or 82.4%(P<0.01) with 1.8g/kg or 0.9g/kg of granulater of BXXX, and FP by 43.3% or 18.3%, respectively. Red phenal gastrexcretion test showed that gastrexcretion rate was increased by 54.2%(P<0.05) and by 59.4%(P<0.05) in rats, but in mice, the effective gastrexcretion was observed (P<0.01), indicating that 'granulated of BXXX' had effects of gastro-myoelectric improvement of rat body surface and increase in rat and mouse red phenal gastrexcretion rate.