高脂血症家族遗传因素与心血管病危险因素的聚集性研究

Association Between Genetic Factors of Hyperlipidemia and the Clustering of Cardiovascular Risk Factors

目的 探讨高脂血症家族遗传因素与心血管病危险因素个体聚集性的关系。方法 采用遗传流行病学研究方法 ,分析高脂血症先证者一级亲属与二级亲属心血管病危险因素的个体聚集性。其中 ,家族性混合型高脂血症家系15个 (共 93人 ) ,家族性高胆固醇血症家系 11个 (共 94人 )。结果 超重、高收缩压、高舒张压、高apoB血症、高血糖、低水平高密度脂蛋白胆固醇 ,这 6种高危因素中 ,心血管病危险因素的个体聚集性随着先证者亲属亲缘系数的下降而下降 (P <0 0 1)。结论 高脂血症家族遗传因素对心血管病危险因素的聚集起着重要作用。

Objective\ To explore the relationship between genetic factors of hyperlipidemia and the clustering of cardiovascular risk factors. Methods\ Twenty six pedigrees including familial combined hyperlipidemia (15 families) with 93 members and familial hypercholesterolemia (11 families) with 94 members were recruited from Beijing suburb. To analysis the difference of clustering of cardiovascular risk factors between first relative and second relative by adopting genetic epidemiology methods. Results\ Among six risk factors including overweight, high SBP, high DBP, high level of apolipoproteinB(apoB), high blood glucose and low high density lipoprotein cholesterol (HDLc), the decreasing of the risk factors clustering was significant correlated with the decline of relationship coefficiency( P< 0 01). Conclusion\ The underlying genetic factors of hyperlipidemia play an important role in the clustering of cardiovascular risk factors.