用QRS积分方法评价西拉普利对急性前壁心肌梗塞的影响

The Evaluation of Cilazapril in the Treatment of Acute Anterior Myocardial Infarction by QRS Scoring System

目的 :用QRS积分方法评价西拉普利对急性前壁心肌梗塞的梗塞面积及心功能的影响。方法 :将 6 4例急性前壁心肌梗塞患者分入西拉普利组 (40例 )与对照组 (2 4例 ) ,治疗组给予西拉普利 2 .5mg/d。对每例患者住院即刻、2 4h、3d、7d、2 1d做常规心电图 ,用Wagner提出的QRS积分方法记录每份心电图分值。入院后 2 1天采用核素心血池测定左室射血分数。结果 :西拉普利组第 2 1日QRS分值 (5 .30± 2 .15 )显著低于对照组 (6 .45± 1.98) ,P <0 0 5 ;西拉普利组左室射血分数 (5 1.9%± 8.8% )明显高于对照组 (45 .2 %± 11.4% ) ,P <0 0 5。结论 :西拉普利可明显减低急性前壁心肌梗塞患者QRS的分值 ,提示西拉普利对防止梗塞的延展、促进心肌梗塞后心功能的恢复有一定作用。

Aim\ To evaluate the effect of cilazapril in the QRS scoring system on infarction size and cardiac function in AMI. Methods Sixty six patients acute anterior myocardial infarction were divided into 2 groups:the cilazapril group and the control group. Patients in cilazapril group were given cilazapril 2.5 mg each day at 8 AM and the conventional electrocardiogram was taken at the time of admission and 24h,7d,21d. Every ECG score was recorded by QRS scoring system suggested by Wagner,Left ventricle ejection fraction(LVEF)was detected by nuclide gating cardiac blood pool imaging at 21 day after admission. Results\ The QRS scores of cilazapril group were lower than that of control group significantly at 21 d(5.30±2.15 vs 6.45±1.98, P <0 05).LVEF of cilazapril group was higher than that of control group (51.9%±8.8% vs 45.2%±11.4%, P <0 05). Conclusion\ Cilazapril can decrease the QRS score of acute anterior myocardial infarction pronouncedly, suggesting that cilazapril has a definitive effect in preventing the infarction extension and promoting the recovery of cardiac function after myocardial infarction.