一平苏对维持性血透患者心血管保护作用的临床观察

Cardiovascular Protection Effect of Cilazapril in Hypertensive Hemodialysis Patients

观察一平苏对维持血透患者的心血管保护作用。方法 :30例有高血压和左室肥厚并维持血透的患者随机分为两组 ,A组 2 0例用一平苏 2 .5mg～ 5mg/d ,B组给予不会影响左室重构的其它药作为对照。 6个月后心脏多普勒超声检查左室重构及功能的情况。结果 :两组虽均有明显降压 ,但一平苏组治疗后LVDd ,IVS ,LVPWD和LVMI均有统计学意义的下降 ,EF和E/A均明显升高。结论 :一平苏不仅可安全有效地降压 ,还可逆转血透患者的左室肥厚及使左室舒张功能改善。

Objective:To investigate the cardiovascular protection effect of cilazapril in hemodialystic patients|(HD). Methods:Thirty HD with hypertension and left ventricular hypertrophy patients were randomly divided into two groups.Group A( n =20) cilazapril 2.5 mg～5 mg,group B( n =10) as control. After six mouths,the left ventricular mass and function were monitored by color Doppler cardiography. Results:BP was decreased in both group.LVDd,IVS,LVPWD and LVMI were decreased in cilazapril group. Conclusion:Cilazapril is not only effective and safe in treatment of hypertension,reversed the ventricular hypertrophy and improved the diastolic function in HD patients also.