一平苏对糖尿病大鼠血管反应性的影响

Effect of Cilazapril on Reactivity of Blood Vessels in Diabetic Rats

目的 观察一平苏 (西拉普利 )对糖尿病大鼠血管反应性的影响。方法 建立STZ所致的糖尿病大鼠血管体外灌流模型 ,以八道生理记录仪检测大鼠肠系膜血管反应持续时间及灌注压的变化。结果 糖尿病大鼠肠系膜血管对去甲肾上腺素的反应持续时间 (9.4± 3.1vs 5 .2± 2 .1,P <0 0 1) ,最高灌压显著降低 (5 .12± 0 87vs 7.81±0 92kPa ,P <0 0 1) ;口服一平苏 8周的糖尿病组大鼠血管反应性无明显改变。

Objective\ To investigate the effect of cilazapril on reactivity of blood vessels in diabetic rats. Methods\ The mesenteric vessels of streptozotocin induced diabetic rats were perfused with Kreb Ringer's solution in vitro,the mesenteric vessels reactivity of diabetic rats was measured by physiological recorder. Results\ The responsive continual time to norepinephrine was delayed significantly(9.4±3.1 vs 5.2±2.1, P <0 01) and the highest perfusion pressure decrease significantly in diabetic rats(5.12±0 87 vs 7.81±0 92 kPa, P <0 01); When taken cilazapril showed no difference in these indexes in diabetic animals.