肺癌患者TXB_2、PAgT、6-Keto-PGF_(1α)的临床意义

Clinical Significance of Determining TXB_2、PAgT、6-Keto-PGF_(1α) in Plasma of Lung Carcinoma Patients

目的 探讨肺癌患者检测TXB2 、PAgT、6 -Keto -PGF1α的临床意义。方法 检测 4 3例肺癌患者及 4 5例正常人的TXB2 、PAgT、6 -Keto -PGF1α,并将肺癌组中的 36例随机分为华法灵钠治疗组和单纯治疗组。在两组患者治疗前及治疗后 ,除检测TXB2 、PAgT、6 -Keto -PGF1α外 ,附加检测纤维蛋白原 (Fib)含量。结果 肺癌组的TXB2 、PAgT较正常人高 ,6 -Keto -PGF1α较正常人低 ,差异高度显著 (P <0 0 1) ;华法灵钠治疗后TXB2 、PAgT、Fib分别较治疗前明显下降 ,6 -Keto -PGF1α较治疗前上升 ,差异均具有显著性 (P <0 0 5～ 0 0 1或P <0 0 5) ,而单纯治疗组上述四项指标均无明显变化 (P >0 0 5)。结论 测定肺癌患者的TXB2 、PAgT、6 -Keto -PGF1α及Fib含量 ,对肺癌的诊断及其病情的判定和治疗有一定的参考价值。

Objective To explore the clinical significance of determining the levels of plasma TXB 2,PAgT,6-Keto-PGF 1α in the lung carcinoma patients.Methods The levels of plasma TXB 2,PAgT and 6-Keto-PGF 1α were determined in 43 patients with lung carcinoma and 45 healthy controls,and 36 cases of 43 patients with lung carcinoma were randomly divided into two groups:(A) conventional treatment plus warfarin sodium,(B) conventional treatment without anticoagulant.We also determined the level of plasma Fib in both group A and group B,besides examined the levels of plasma TXB 2,PAgT and 6-Keto-PGF 1α before and after treatment.Results Statistical analysis showed that the levels of TXB 2 and PAgT were significantly higher,but the levels of 6-Keto-PGF 1α was significantly lower in the patients with lung carcinoma than those in healthy controls(P<0 05～0 01).The levels of TXB 2,PAgT and Fib in group A were significantly lower,but the level of 6-Keto-PGF 1α was significantly higher in group A after treatment than before treatment(P<0 05～0 01).While these four indexes in group B did not significantly change(P>0 05).Conclusion The determination of plasma TXB 2,PAgT and 6-Keto-PGF 1α for lung carcinoma patients are helpful in diagnosis and treatment of lung carcinoma.