骨复生对激素性股骨头缺血坏死家兔血液流变学的影响

THE INFLUENCE OF GUFUSHENG ON BLOOD RHEOLOGY OF RABBITS WITH STEROID-INDUCED AVASCULAR NECROSIS OF FEMORAL HEAD: An Experimental Study

给日本大耳白家兔每周 2次肌注醋酸氢化可的松 8mg· kg- 1 ,造成激素性缺血性股骨头坏死的病理模型 ,通过设立骨复生组、模型对照组、空白对照组 ,观察血液流变学指标。结果发现骨复生具有降低全血低切粘度、血浆粘度、红细胞压积、红细胞聚集指数、红细胞刚性指数及血浆纤维蛋白原含量的作用。

To study the influence of GUFUSHENG on blood rheology of rabbits with Steroid-induced Avascular Necrosis of Femoral Head, 30 white Japanese rabbits with big ear were divided into 3 groups randomly: GUFUSHENG group and two control group ( model group, blank group). Except for the blank group, the others were made pathological models by injecting hydrocortisone acetate twice every week. After completing the modeling process, the indexes of blood rheology were analyzed. The results showed that GUFUSHENG could lower the whole blood viscosity, plasma viscosity, hematocrit, hemagglutination index, erythrocyte fragility index, and the level of plasma fibrinogen, which might be the mechanism of curing steroid-induced Avascular Necrosis Head of Femoral Head with GUFUSHENG.