摘要
目的 :观察胃癌癌前病变组织中 p2 1ras、c- erb B- 2及 p53基因蛋白的表达及胃炎消的可能调控作用。方法 :胃镜病理证实为中、重度异型增生和不完全性结肠化生病例共 34例 ,分为胃炎消治疗组 19例 ,维酶素对照组 15例 ;治疗前、后胃粘膜固定部位活检标本作 p2 1ras、c- erb B- 2癌基因及 p53抑癌基因蛋白 L SAB免疫组化染色。结果 :胃炎消组症状总有效率 89.4 7% ,对异型增生疗效尤以中度为好 ,作用优于对照组。 p2 1ras、c- erb B- 2及 p53蛋白在胃癌癌前病变组织中均有过表达 ,且其表达随病变的进展而增高 ;胃炎消能使 p2 1ras及 c- erb B- 2蛋白的表达明显减弱 ,但对 p53抑癌基因蛋白表达的作用不明显。结论 :胃炎消对胃癌癌前病变有良好的治疗作用 ,并对胃癌癌前病变组织中与细胞增殖信号传递有关的p2 1ras、c- erb B-
Objective:To explore the p21 ras 、c erbB 2 and p53 oncogene protein expression in cases with precancerous lesion of gastric carcinoma and the regulation effects of Wei Yan Xiao.Methods:34 pathologically diagnosed cases with medium and advanced heteroproliferation and incomplete intestinal metaplasia were divided into Wei Yan Xiao group (19 cases) and weimeisu group.Detections were made on the same spot for the measurement of p21 ras and c erbB 2 oncogene expression and p53 protein by using immunohistochemistry. Results: The total effective rate of Wei Yan Xiao group was 89.47%.Heteroproliferation was relieved with better effectiveness than weimeisu group.The p21 ras and c erbB 2 oncogene expression and p53 protein were also observed which was increased with the advancement of the gastric carcinoma stages.Conclusions:Wei Yan Xiao was effective in treating precancerous lesion of gastric carcinoma and could control the p21 ras and c erbB 2 oncogene expression.
出处
《浙江中西医结合杂志》
2001年第6期334-336,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金
广东省自然科学基金课题 !编号 :970 2 2 8
