肉鸡肺动脉高压综合征自然病例肺微细动脉肌型化的观察

Muscularization of pulmonary arterioles in field cases of broilers with pulmonary hypertension syndrome

随机抽取 12羽与缺氧有关的肺动脉高压综合征 (PHS)自然病鸡和 12羽同种、同龄健康AA肉鸡 ,用组织形态学方法对患PHS肉鸡和健康肉鸡肺细小动脉结构变化进行定量检测和比较分析。结果显示 :患PHS肉鸡的肺细小动脉血管管壁面积与管总面积之比 (WA/TA)、中膜厚度与管外径之比均极显著高于健康肉鸡 (P <0 0 1) 。对直径小于 6 0 μm和直径小于 2 0 0 μm的肺微细动脉的末稍厚壁血管百分率和三型血管占位比例进行测定 ,结果患PHS肉鸡的肌化百分率也极显著高于健康肉鸡 (P<0 0 1) 。组织病理学检查显示 ,血管内膜及中膜细胞增生、肥厚。揭示缺氧性肺动脉高压肉鸡的肺血管发生了以非肌性动脉肌型化 ,肌性动脉管壁增生。

Twelve field cases with pulmonary hypertension syndrome in broilers due to hypoxia and twelve healthy birds from the same flock as control were randomly selected for histomorphological evaluation of pulmonary arterioles.The histopathological alterations of pulmonary arterioles in broilers with PHS and in controls were measured and analyzed.The results indicated that the ratio of vessel wall area to total vessel area(WA/TA)and ratio of mean medial thickness in pulmonary arteries(mMTPA)to diameter of vessel were more significantly increased(P<0 01)in sick birds than in healthy birds and that the percentage of pulmonary vascular muscularity were also significantly increased(P<0 01)by measuring the percentage of thick walled peripheral lung vessels at diameter<200 μm and <60 μm.Histopathological observation showed the intimal cellular proliferation and medial hypertrophy.Therefore,it might be concluded that the vascular remodeling characterized by the muscularization of non muscular arterioles and the proliferation and hypertrophy of the muscular vessels had been occurred in the field cases with pulmonary hypertension syndrome induced by hypoxia.