具有生物活性的有机硅化合物的研究 Ⅹ.3-(三甲硅基)丙基硫代(N-取代)乙酰胺的合成和质谱研究

Studies on Organ osilicon Compounds with Biological Activity Ⅹ. Synthesis of 3-(Trimethylsilyl)propylthio(N-substituted)acetamide and Study on Mass Spectra

本文合成了15个3-(三甲硅基)丙基硫代(N-取代)乙酰胺类化合物.通过对这些化合物的红外光谱和核磁共振(~1H,^(13)C)谱的研究,确证了它们的表征结构.质谱数据表明,这类化合物的裂解机理主要取决于硅烷、酰胺和硫醚的断裂方式.这类化合物的毒性较大,不利于用作抗癌试验.

Fifteen 3-(trimethylsilyl)propylthio (N-substituted) acetamides were synthesized. Their structure was studied by IR and NMR (~1H, ^(13)C). The MS of these produts were determined. It has been found that fragmentation mechanism, is dependent mainly on the fragment of Si—C, amide bonds and thio-ether bonds, these compounds are highly toxic.