三丁基锡羧酸酯的结构表征及其生物活性研究

The Structure and Biological Activity of Tributyltin Carboxylates

合成了三十个三丁基锡羧酸酯Bu_3SnO_2CR(R=烷基、芳基、芳氧甲基和呋喃基).通过对它们的红外光谱、核磁共振谱(^(13)C,^(119)Sn)的研究,表明羰基红外吸收频率与锡原子的配位数有密切关系,同样分子结构上的微小变化明显地表现在δ_(^(119)SN)上,对位取代基苯甲酸酯的δ_(^(119)SN)与苯环上取代基的Hammett常数(σ)之间存在良好的线性关系: δ_(^(119)SN)=19.11σ+110.612 n=7.r=0.9955着重研究了部分化合物在经济作物上的抗病原菌能力,结果表明,这是一类具有广谱性的有机锡化合物,抗菌活性优于对比药剂朴海因,接近或相当于多菌灵.它们同时具有较强的除草活性.

Thirty tributyltin oarboxylates were synthesized by using(Bu_3Sn)_2O(TBTO)as a raw material. The struoture of these compounds, was distinguished by studing of their IR and NMR. The results have shown that absorption frequencies of carbonyl group markedly depend on the coordination number of the tin atom. The chemical shifts of ^(119)Sn, ^(13)C and ~1J(^(119)Sn-^(13)Sn)coupling constant of the compounds have been determined. It could be found a small structural change around the tin atom can be reflected on ohemical shift ^(119)Sn. For tributyltin arylcarboxylates, we have found that there is a relationship between ohemical shift ^(119)Sn and Hammett constant of the para-substituent of the corresponding compounds:δ_(110Sn)=19.11σ+110.62 n-7, r=0.9955The biological activities of same compounds have been studied. They may be used for fungioides of fruiter.