1,3-手性转移反应的研究 (4R)-和(4S)-4-甲基-(E)-2-辛烯醇的合成

Studies on 1,3-Chiral Shift Reaction Synthesis of(4R)and(4S)-4-Methyl-(E)-2-Octenol

以手性辛烯二醇双酯6和7与甲基锂铜反应,经1,3手性转移,分别生成立体选择性高的(4R)和(4S)-4-甲基-辛烯醇酯8a

An efficient stereospecific synthesis of (4R) and (4S)-4-methyl-(E)-octenolsstarting from D-glyceraldehyde acetonide was reported.The key steps are the γ-alkylation of the allylic di-N-phenylcarbamate 6 (syn way) and dibenzoate 7 (antiway) with Li_2Cu_3(CH_3)_5.