驱虫斑鸠菊化学成分的研究

Studies on Chemical Constituent of Vernonia Anthelmintica Willd

从驱虫斑鸠菊(Vernonia anthelmintica Willd)的种子中分离到十个化合物,经理化性质及波谱分析鉴定为斑鸠菊黄烷苷-对羟苯甲酯(p-Hydroxy benzoyl-Vemovan)(1)、斑鸠菊黄烷苷(Vernovan)(2),为未见文献报道新化合物.并发现斑鸠菊大苦素(Vernadalin)(3)、斑鸠菊醇(Vernodalol)(4),对 P_(388)白血病细胞有抑制作用.5、6、7、8及10为该属植物中首次获得.

The seeds of Vernonia anthelmintica Willd (Compositaceae) were used in Xinjiangfolk medtcine for the treatment of antivitiligo.Two new flavan glucoside:p-hydroxybenzoyl-Vernovan (1) and Vernovan (2) were isolated from the seeds andtheir structures were elucidated by spectral analysis.The other components wereidentified as Vernodalin (3),Vernodalol (4),Butein (5),3,4,2',4',5'-pentahydroxy-6'-methoxy-2-methyl-chaltone (6),β-Amyrin (7),β-sitosterol-β-D-glucoside (Dau-costerol 8),Vernolic acid (9) and Stigmasterol (10).