珠母贝糖胺聚糖的结构初探及其生理活性

The preliminary probe of structure and physiological activity of glycosaminoglycan from Pinctada martensis

以马氏珠母贝全脏器为原料提取、纯化后所得的珠母贝糖胺聚糖PG2 - 3- 2 ,经醋酸纤维素薄膜电泳显示其迁移率相对接近于 6 -硫酸软骨素 (C - 6 -S) ,红外光谱类似于C - 6 -S。抗肿瘤试验结果显示 :PG2 - 3- 2对体内S180肉瘤和艾氏腹水癌可显著增敏临床抗癌药的抑瘤作用 ,抑瘤率分别达 6 1.96 %与 46 .3%。并有抗凝血作用。

Glycosaminoglycan PG2-3-2 from whole viscera of Pinctada martensis was obtained after extraction and purification. The fraction showed that its migration rate was relatively near to that of Chondroitin 6-sulphate(C-6-S) by acetate film electrophoresis. The infrared spectra (IR) of it was similar to that of C-6-S. The result of antitumor test in vivo demonstrated that PG2-3-2 could obviously enhance the sensitivity of inhibitive function of clinical antiturmor drugs, the inhibition rates of which to Sarcoma 180 and Ehrlich's Ascipes Carcinoma(EAC) were 61.96% and 46.3% respectively. Moreover, PG2-3-2 had certain function of anticoagulant by the test in vitro.