创伤性关节炎患者血清和关节液中自由基水平及意义

Level of Free Radicals in Serum and Synovial Fluids from Ratients with Traumatic Arthritis and Its Significance

目的：了解创伤性关节炎患者血清和关节液中自由基水平，探讨一氧化氮（ＮＯ）和氧自由基在创伤性关节炎发生发展中的作用。方法：检测了２７例损伤引起的创伤性膝关节炎患者和２０例健康对照者血清和关节液中ＮＯ和超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）的含量。结果：健康对照者关节液中ＮＯ和ＭＤＡ含量低于血清中含量（Ｐ＜０．０５），ＳＯＤ含量血清和关节液中无差异（Ｐ＞０．０５）；患者关节液中ＮＯ和ＭＤＡ含量显著高于血清中含量（Ｐ＜０．０１），ＳＯＤ含量明显低于血清中含量（Ｐ＜０. ０５）。结论：创伤性关节炎患者关节液中存在高水平自由基，ＮＯ和氧自由基在创伤性关节炎的发病机制中具有重要的作用。

Objective To understand the level of nitric oxide(NO)and oxygen radicals in serum and synovial fluids from patients with traumatic arthritis and investigate the role of them in traumatic arthritis. Methods: Contents of NO,superoxide dismutase (SOD) and NDA in serum and synovial fluids from 27 patients with knee traumatic arthritis and 20 healthy people were assayed. Resuults:In healthy people,contents of NO and MDA in serum were lower than those in synovial fluids (P<0. 05)but SOD content no difference (P>0. 05);In patiens with traumatic arthritis,contents of NO and MDA in serum was markedly higher than those in synovial fluids(P＜0. 01)as well as SOD content was obviously lower(P＜0. 05). Compare with healthy people,contents of NO and MDA were high and SOD was lowin serum from patients but no difference (P＞0. 05). Conclusions:There is a higher Level of free radicals in synovial fluids from patients with traumatic arthritis and NO and oxgen radicals may play an inportant role in the developing process of traumatic arthritis.