冠状动脉内磁化支架置入术后冠状静脉窦血中NO与ET-1水平的变化

Changes in the levels of serum nitric oxide and plasma endothelin-1 in coronary sinus after intracoronary magnetized stent placement

目的 :观察冠心病患者冠状动脉内置入磁化支架后冠状静脉窦血中一氧化氮 (NO)与内皮素 - 1(ET- 1)水平的变化 ,探讨磁化支架防治冠状动脉再狭窄的机制。方法 :经皮腔内冠状动脉成形术及冠状动脉内支架置入术的冠心病患者随机分为磁化支架组 (2 3例 )及非磁化支架对照组 (16例 )。经股静脉将 6 F右冠状动脉造影导管置入冠状静脉窦采血 ,采用 Griess法及非平衡法分别测定冠状动脉内支架置入术前及术后 6 h内冠状静脉窦血中 NO及ET- 1的水平。结果 :磁化支架组术后 6 h冠状静脉窦血中 NO含量较对照组相比显著升高 (P<0 .0 1) ;磁化支架组ET- 1水平的改变 ,包括术后即刻降低 P<0 .0 1)与 6 h回升 (P<0 .0 1)都不如对照组明显 ,两组 ET- 1水平在 3h有显著性差异 (P<0 .0 5 )。结论 :冠状动脉内磁化支架置入术后 NO升高与 ET- 1水平变化趋缓反映了靶区血管局部内皮细胞功能改善 。

AIM: To investigate the effects of intracoronary magnetized stent placement on the level of serum nitric oxide (NO) and plasma endothelin 1(ET 1) in coronary sinus in patients with coronary heart disease after percutaneous transluminal coronary angioplasty(PTCA). METHODS: Patients with coronary heart disease randomly received magnetized or unmagnetized stent placement as controls. Placing a right coronary artery catheter into the coronary sinus, we collected blood samples of the patients during the first 6 h after PTCA and stent placement. Levels of serum NO and plasma ET 1 were determined by Griess method and non balanced method. RESULTS: Serum level of NO of the magnetized stent patients was significantly higher than that of the controls( P <0.01), while plasma level of ET 1 didn't change as markedly as the controls( P <0.05). CONCLUSION: Higher level of NO and smooth changes of ET 1 level reflect the improvement of endothelial cell function after magnetized stent placement, which may play some role in the reduction of acute coronary spasm and long term restenosis.