丙型肝炎患者外周血B细胞和T细胞及其亚群的研究

Study on B lymphocyte,T lymphocyte and its subgroups in peripheral blood in patients with hepatitis C

目的 了解丙型肝炎患者外周血 B细胞和 T淋巴细胞及其亚群的变化。方法 应用单克隆技术测定 38例丙型肝炎患者外周血 B细胞和 T淋巴细胞亚群的水平并以 35名健康人作对照。结果 丙型肝炎患者外周血 B细胞数显著地高于正常人 (P<0 .0 0 1)、CD3、CD4、CD4/ CD8显著低于正常人 (P<0 .0 1,P<0 .0 0 1)。结论 丙型肝炎患者为一种自身免疫调节异常的疾病。

Objective To study the changes of B lymphocyte,T lymphocyte,and its subgroups in peripheral blood in patients with hepatitis C.Methods B lymphocyte,T lymphocyte and its subgroups in peripheral blood in 38 patients with hepatitis C and 35 normal controls were detected with monoclonal technigue.Results The level of B lymphocyte were significanty higher than those in normal people( P <0.001).But CD 3、CD 4 and the ratio of CD 4/CD 8 were obviously lower( P <0.01, P <0.001).Conclusion Hepatitis C is a kind of selfi-mmunity disease with abnormal immunoregulation.