血清CA19-9检测在消化道肿瘤诊断中的临床意义

Clinical Value of Serum CA19-9 Assays In The Diagnosis of Gastrointestinal Carcinoma

目的 :评价血清CA19 9检测对消化道肿瘤诊断的临床价值。方法 :应用酶联免疫吸附试验 (ELISA)法 ,检测 194例消化道肿瘤患者和 80例术后无瘤患者血清中的CA19 9含量。结果 :胰腺癌患者血清CA19 9含量和阳性率为 16 5 94± 90 .34u/ml和 88 89% ,胆系癌为 12 2 9± 89 38u/ml和 81 82 % ,肝癌为 141 39±92 75u/ml和 77 78% ,胃癌为 10 3 6 7± 10 2 16u/ml和 5 9 38% ,肠癌为 5 9 40± 72 5 7u/ml和 5 1 0 6 % ,食管癌为2 0 83± 2 0 .45u/ml和 2 2 2 2 % ,术后无瘤患者为 12 2 2± 10 .92u/ml和 2 5 %。胰腺癌、胆系癌、肝癌、胃癌和肠癌患者血清CA19 9含量和阳性率明显高于术后无瘤患者 ,经统计学处理有显著差异 (P <0 0 1)。食管癌患者血清CA19 9含量和阳性率和术后无瘤患者比较无统计学差异 (P >0 0 5 )。若将血清CA19 9临界值提高到 10 0u/ml,诊断消化道肿瘤的特异性达 10 0 % ,但敏感度下降。结论 :血清CA19 9抗原是诊断胰腺癌、胆系癌、肝癌、胃癌和肠癌的一项特异性较高、敏感度较强的肿瘤标志物 ,有助于术后病情随访监测和判断预后 。

Objective: To evaluate the clinical value of serum CA19 9 in the diagnosis of gastrointestinal cancer.Methods:The serum levels of CA19 9 were determined by enzymelinked immumo sorbent assay in 194 patients with gastrointesinal cancer and 80 tumor free patient:Results The serum levels of CA19 9 and their positive rates in patients with pancreatic cancer,biliary cancer,biliary cancer,liver cancer,gastric cancer,colorectal and esophagus cancer are:165 94±90.34u/ml and 88 89%,122 9±89 38u/ml and81 82%,141 39±92 75u/ml and 77 78%,103 67±102 16u/ml and 59 38%,59 40±72 57u/ml and 51 06%,20 83±20.45u/ml and 22 22%,respectively.The serum levels of CA19 9 and their positive rates in tumor free patients is 12 22±10.92u/ml and 2 5%.The serum levels of CA19 9 and their positive rate patients with pancreatic,biliary,liver,gastric and colorectal cancer are significantly higher than that of tumor free patients(P<0 01).There’s no difference between esophagus cancer and tumor free patients statistically(P>0 05).If the critical value of CA19 9 was raised to a level of 100u/ml,its specificity in diagnosing gastrointestinal tumor reached a degree of 100%,while its sensitivity declined.Conclusion:Serum CA19 9 is a tumor marker with high specificity and sensitivity in diagnosing of pancreatic,biliary,Iiver,gastric and colorectal cancer and it contributes to postoperative follow up survey and prognosis judgement,whereas it has little value in diagnosing esophagus cancer.