良性前列腺增生中的高度前列腺上皮内瘤初步观察

Initial observation of high grade prostatic intraepithelial neoplasia in benign prostate hyperplasia

本文观察良性前列腺增生 (BPH)中的高度前列腺上皮内瘤 (HPIN)现象。回顾性分析 5 4例行耻骨上前列腺摘除术患者的前列腺标本切片。统计其中HPIN的发生率 ,并结合患者术前血PSA值 ,分析HPIN与非HPIN之间的血PSA值差别。结果发现 5 4例患者中 2 2例有HPIN表现 ,占总数的 40 .7%。HPIN组与非HPIN组之间的血PSA值无显著性差异。在本组BPH患者中 ,HPIN表现占有一定比例 ,因此认为HPIN现象并非前列腺癌 (Pca)专有。本组中HPIN比例偏高与患者平均年龄较大有关。本研究通过血PSA测定尚无法简单区分HPIN和非HPIN。对于HPIN现象 ,一方面应提高警惕 ,密切随访 ;另一方面也不必盲目悲观 ,毕竟HPIN只是一种前列腺癌的前驱表现 。

suprapubic prostatectomy specimens were retrospectively analysed.The results showed 22 HPIN (40.7%) in total 54 specimens.The pre operational PSA values between HPIN and non-HPIN were also compared.The PSA values had no difference between two groups (HPIN and non-HPIN).In this BPH series,HPIN is not a rare phenomenon.HPIN was not only found in prostate cancer (Pca).May be the old age caused the high percentage of HPIN.PSA can not be an exclusive index to distinguish HPIN and non-HPIN.If HPIN was found,careful followup should be done.On the other hand,HPIN was just a precursor of Pca,not Pca itself.