垂体腺瘤中PCNA蛋白表达的研究

Study on the expression of PCNA protein in pituitary adenoma

目的 探讨良性垂体腺瘤中增殖细胞核抗原 (PCNA)蛋白表达与肿瘤发生及生物学行为的关系。方法 应用免疫组化 ABC法检测 5 8例垂体腺瘤中 PCNA蛋白的表达。结果 PCNA的表达在垂体腺瘤患者中 ,复发者 PCNA增殖指数明显高于非复发患者 (P<0 .0 5 )。在出血组与非出血组、囊性变组与非囊性变组及巨大型组与非巨大型组中 ,PCNA蛋白的表达均无显著性差异 (均 P >0 .0 5 )。结论 PCNA蛋白表达较准确地反映了垂体腺瘤细胞的增殖活性 ,可作为判断复发和预后的指标之一。

Objective To explore the relationship between the protein expression of PCNA and biological behavior science in benignant pituitary adenoma.Methods The protein expression of PCNA in 58 patients with pituitary adenoma were determined by ABC immunohistochemical method.Results The PCNA index was significantly higher in the patients with recurrent pituitary adenomas than in nonrecurrent ones( P <0.05).There was no significantly difference between bleeding and unbleeding group,cystic and noncystic group,large type and unlarge type group(P> 0.05 respectively).Conclusion The protein expressions of PCNA reflected the proliferative activties of pituitary adenomas, and could be taken as one of the indicators to evaluate recurrence and prognosis of the tumor.