高强度聚焦超声热疗治疗晚期胰腺癌的初步临床应用

The preliminary clinical results of the treatment for advanced pancreatic carcinoma by high intensity focused ultrasound

目的 了解高强度聚焦超声热疗 (HIFU)治疗晚期胰腺癌的效果及安全性。方法 采用FEP BY0 1型超声热疗机对 2 1例晚期胰腺癌患者进行HIFU治疗。结果 治疗后 88% (15 /17)患者疼痛症状明显缓解 ,癌组织超声回声都出现不同程度地增强 ,血供明显减少或消失 ,但是治疗后肿瘤大小及CT值无明显改变 ,正电子发射计算机断层显象检查提示癌组织已被杀死。本组未发生皮肤烧伤、胰瘘、出血、胰腺炎、胃肠道穿孔等并发症。HIFU后本组平均生存期为 7 6个月。

Objective To evaluate the clinical effect and safety of high intensity focused ultrasound (HIFU) for the treatment of advanced pancreatic carcinoma. Methods 21 cases of advanced pancreatic carcinoma were treated by FEP BY01 pyrotherapier (HIFU). Results After HIFU, abdominal pain was relieved in 88% of patients (15/17), ultrasonic echo of carcinoma tissue was enhanced in all patients, the bloodstream decreased significantly or disappeared, the tumor size and CT value had no significant change, PET examination showed that carcinoma was inactivated effectively, although the tumor size as evaluated by CT scan did not experience a shrinkage. There were no complications such as skin burns、pancreatic fistula、bleeding、 pancreatitis and perforation during the process. The mean survival time of the patients after HIFU was 7 6 months. Conclusion HIFU as a new local treatment effects a satisfactory palliation for patients with advanced pancreatic carcinoma.