百忧解治疗卒中后抑郁的临床研究

EFFECT OF FLUOXETINE ON TREATMENT OF POST-STROKE DEPRESSION

目的 :探讨百忧解治疗卒中后抑郁的临床疗效。方法 :对 58例卒中后抑郁患者应用百忧解(治疗组 32例 )和脑复康 (对照组 2 6例 )进行对照治疗 ,两组同时应用脑血管病治疗药物。采用Zung自评量表、汉密尔顿抑郁量表 (HAMD)、日常生活自理能力量表 (Barthel指数记分 )和神经功能缺损程度评定疗效和功能改善状况。结果 :百忧解治疗组的显效率明显优于对照组 (P <0 .0 1)。治疗后治疗组Zung量表、HAMD量表减分率与对照组比较 ,差异有高度显著性 (P <0 .0 1) ,神经功能缺损程度积分值降低与Barthel评分提高 ,治疗组高于对照组 (P <0 .0 1)。百忧解主要副反应为失眠、焦虑、乏力、恶心和震颤。结论 :百忧解治疗卒中后抑郁有效 ,能改善神经功能 。

Objective:To investigate the effect of fluoxetine on post stroke depression(PSD).Methods:Fitty eight patients with PSD were observed and divided into two groups randomly.Of all 32 patients were treated with fluoxetine while 26 patients with acetamidepyrrolidone as contrast group.The effect were measured by Zung self Rating depression scae,Hamilton depression rating scale(HAMD) and activity of daily living scale (Barthel Index),nerve functional defect degree.Results:The therapeutic efficacy in treatment group was better than that of contrast group(P<0.01).The scores of Zung,HAMD after fluoxetine treatment were lower than those of contrast group.Nerve functional defect degree and Barthel index were better than those of contrast group significantly(P<0.01).The side effects of fluoxetine were insomnia,anxiety,nausea and tremor.Conclusion:Fluoxetine may the effective in treatment of PSD and could improve neurological functions.