3-羟基-2,2-二甲基丙酸甲酯的合成

Synthesis of 3-hydroxy-2,2-dimethylproranic methyl ester

以异丁醛、甲醛等为原料 ,通过羟醛缩合生成 3-羟基 - 2 ,2 -二甲基丙醛 ,然后在甲醇溶剂中碱性条件下 ,用氯气氧化、酯化 .采用正交实验法详细地研究了氢氧化钠量和氯气量对第二步反应的影响 ,并找出了最佳反应条件 .

Methyl 3-hydroxy-2,2-dimethylpropionate was synthesized by direct conversion of 3-hydroxy-2,2-dimethylpropionaldehyde prepared by aldol condensation of isobuthylaldehyde and formaldehyde,to the methyl ester using chlorine and sodium hydroxide in methanol. And optimum reaction conditions, such as the amount of chlorine and sodium hydroxide, reaction temperature were established.