肝硬化患者幽门螺杆菌感染的差异性

The Different Strain Infection of Helicobacter Pylori in Cirrhotic Patients

观察肝硬变患者幽门螺杆菌感染的差异性及其对病情的影响。结果发现 :随着肝功能的减退 ,Child A组 ,Child B组 ,Child C组 HP的感染率逐步升高 ,Cag A、Vac A阳性率也逐步升高 ,Child C与各组比较 HP的感染率 ,Cag A、Vac A 的阳性率均显著增高 ,差异有显著性 ( P<0 .0 5 ) ,胃排空无差异 ( P>0 .0 5 )。其余各组间比较无差异 ( P>0 .0 5 )。提示 :肝硬变患者与对照组比较 HP的感染率及其菌株无显著差异 ,胃的排空与 HP的感染无关 ,肝脏功能状况与 HP感染相关性有待进一步研究。

In order to study the different strain infection of helicobacter pylori (HP) in cirrhotic patients and its influence on the patients, 95 patients and 25 healthy volunteers were studied HP was examined by C 14 urea breath test and rapid urease test, Cag A and VacA of HP were measured using immunblot techniques Gastric emptying were measured by ultrasound type B Every patients also received gastroscopic examination and liver function test was performed According to Child pugh criteria, 95 patients were divided into three groups: ChildA, ChildB ChildC Also, the patients were divided into the gastric lesion group and gastric normal group according to the findings of gastrocopic examination Results showed no significant difference was found between the case group and control group in the infection rate of HP, CagA and VacA positive rate and gastric emptying time Also, there was no significant difference in the above mentioned items between the gastric lesion group and gastric normal group It was concluded that the status of HP infection does not seem to play a role in the development of cirrhotic status and delayed gastric emptying in these patients