急性心梗后即刻给予心得安对左室重塑影响的实验研究

Experimental Study on the Effects of Immediate Administration of Inderal on Postinfarction Left Ventricular Remodeling of the Rabbit

在兔急性心梗 (AMI)模型上观察 AMI后即刻应用心得安对兔左室重塑的影响。结果显示 :与心梗 -安慰剂组比较 ,心梗 -心得安组未缩小梗塞范围 ,也未降低膨胀指数 ;与假手术 -心得安组比较 ,心梗 -心得安组的心室重量、左室容积指数和室壁应力显著升高 (2 .6 5± 0 .11) g/ kg vs(2 .32± 0 .11) g/ kg,P<0 .0 5 ;(2 .2 2± 0 .2 3) ml/ kg vs(1.70±0 .12 ) ml/ kg,P<0 .0 0 1;(0 .84± 0 .0 7) vs(0 .75± 0 .0 5 2 ) ,P<0 .0 5 ;而与心梗 -安慰剂组间无显著差异。心梗 -心得安组与心梗 -安慰剂组比较 ,心率显著降低 [(15 3± 6 .36 ) min- 1 vs(2 2 5± 4.0 8) m in- 1 ,P<0 .0 0 1) ],但左室舒张末压、 +dp/ dtmax和心脏指数两组间无显著差异。上述结果表明 :兔

The effects of immediate administration of inderal following acute myocardial infarction on left ventricular remodeling were studied in acute myocardial infarction model of the rabbit. The results showed that there was no significant difference in the infarct size and expansion index between the infarct inderal group and the infarct placebo group. As compared with sham surgery inderal group, infarct inderal group had a higher ventricular weight, left ventricular volume index and left ventricular wall stress [(2 65±0 17) g/kg vs (2 32±0 11) g/kg, P <0 05; (2 22±0 23) ml/kg vs (1 70±0 12) ml/kg, P <0.001; (0 84±0 07) vs (0 75±0 052), P <0 05, respectively], but there was no significant difference between the infarct inderal group and infarct placebo group. Heart rate in the infarct inderal group was significantly decreased as compared with that of infarct placebo group [(153±6.36) min -1 vs (225±4.08) min -1 , P <0.001], but there was no significant difference in left ventricular end diastolic pressure, +dp/dt max and cardiac index between the two groups. It was suggested that immediate administration of inderal postinfarction had no preventive effect on left ventricular remodeling.