男性非淋病性尿道炎患者支原体的检测和对10种抗菌药物的敏感性试验

Mycoplasma Detection of Male Patients with Non-gonococcal Urethritis and Study of Their Susceptibility to 10 Antimicrobial Agents

为了解解脲支原体和人型支原体在男性非淋病性尿道炎 (NGU)中的致病作用和它们的体外药物敏感状况 ,运用微量肉汤稀释法对支原体进行 10种抗菌药物的敏感性测定。在 2 6 8例疑为 NGU的男性患者中 ,85例 (31.7% )支原体培养阳性 ,其中 U U感染 71例 (2 6 .5 % ) ,MH感染 4例 (1.5 % ) ,MH+UU感染 10例 (3.7% ) ,85例阳性患者的支原体株对 10种抗菌药物的高度敏感性依次为交沙霉素 (81.2 % )、克拉霉素 (73.0 % )、司巴沙星 (70 .6 % )、罗红霉素 (6 7.1% )、阿奇霉素 (5 5 .3% )、强力霉素 (2 8.2 % )、美满霉素 (16 .5 % )、氧氟沙星 (15 .3% )、环丙沙星 (14.2 % )、培氟沙星 ,发现 11株对四环素类和喹诺酮类 (除司巴沙星外 )交叉耐药。认为支原体的定期耐药性监测 。

To explore the pathogenesis of U. urealytica (UU) and M. hominis (MH) in male non gonococeal urethritis (NGU) and information about their drug susceptibility in vitro , susceptibility of mycoplasma to 10 antimicrobial agents was determined by using microdilution method. In 268 male patients suspected with NGU, 85 (31.7 %) were positive for mycoplasma culture. Among them, 71 cases (26.5 %) were diagnosed as having UU infection, 4 cases (1.5 %) having MH infection, 10 cases (3.7 %) having both MH and UU infection. For the strains of mycoplasma in 85 cases, the susceptibility to 10 kinds of antimicrobial agents was put in order: Josamycin (81.2 %), clarithromycin (73.0 %), Sparfloxacin (70.6 %), Roxithromycin (67.1 %), Azithromycin (55.3 %), Doxycycline (28.2 %), Minocycline (16.5 %), Ofloxacin (15.3 %), Ciprofloxacin (14.2 %), perfloxacin. The cross resistance of 11 strairs to fluoro quinolores (except sparfloxacin) and tetracycline was found. It was suggested that monitoring the variance of resistance of mycoplasma was important for directing drug use in clinical practice.