抗高血压因子对大鼠血管平滑肌钙内流的影响

Effects of Antihypertensive Factor on Ca^2+ uptake of Vascular Smooth Muscle in Rats

实验观察了从原发性高血压病患者红细胞中提取的抗高血压因子(AHF)对自发性高血压大鼠(SHR)、肾性高血压大鼠(RHR)和正常血压的WKY大鼠和Wistar大鼠主动脉和肠系膜动咏平滑肌Ca^(2+)内流的影响。结果表明,SHR和RHR的肠系膜动脉Ca^(2+)内流显著高于主动脉;AHF可显著抑制SHR和RHR主动脉和肠系膜动脉Ca^(2+)内流,抑制作用呈剂量依赖性,且对肠系腆动脉Ca^(2+)内流抑制作用更明显;AHF也可抑制正常动物血管平滑肌Ca^(2+)内流。本工作提示,AHF的降压机制可能与其抑制血管平滑肌特别是小动脉血管平滑肌Ca^(2+)内流有关。

The effects of antihypertensive factor (AHF) from erythrocytes of essential hypertensive subjects on Ca2+ uptake of vascular smooth muscle in spontaneously hypertensive rats (SHR), renal hypertensive rats (RHR) , Wistar Kyoto (WKY) rats and Wistar rats were examined. The results indicated that Ca2+ uptake of mesenteric artery was greater than that of aorta from both SHR and RHR. AHF inhibited significantly Ca2+ uptake into mesenteric artery and aoeta from both SHR and RHR in a dose-dependent manner, and inhibitory effects were more potent in mesenteric artery than in aorta. AHF could also inhibit Ca2+ uptake of vascular tissues from normotensive rats.