米非司酮对晚孕引产大鼠脑组织的影响

The Effects of Mifepristone on the Cerebral Tissue of Term Pregnant Rats

为探讨米非司酮引产对母鼠脑组织超微结构的影响 ,将 1 0只孕鼠随机分为实验组和对照组 ,每组各 5只。孕第 2 0天给实验组灌服米非司酮 ( 1 1 .5± 1 mg)加麻油 ( 1 ml)引产 ,对照组灌服麻油 ( 1 ml)。产后取母鼠右侧大脑顶叶皮质组织进行电镜观察及体视学分析。结果 :与对照组相比实验组母鼠脑组织可见 :( 1 )神经细胞肿胀 ;( 2 )神经毡局部破坏 ;( 3 )突触连接减少 ;( 4)间质水肿 ;( 5 )体视学示对照组线粒体数密度大于实验组 ,体积密度两组无显著差异。结果提示 ,米非司酮晚孕引产可造成母鼠脑组织缺血缺氧性损害。

The effects of mifepristone on the cerebral ultrastructure of term pregnant rats were studied. Ten pregnant rats were divided randomly into an experimental group (n=5) and a control group (n=5) . At the 20th day of gestation, the experimental rats were given sesame oil 1 ml and mifespristone 11.5±1 mg, while the control rats weregiven only sesame oil 1 ml. After labour, the cortical tissues of the right parietal cerebrum were obtained and prepared for electron microscopic observation and analysed by stereology. Results: compared with the control group, the experimental group showed the following morphological changes: (1) Neurons swelled and membranous cytoplosmiz organoids decreased; (2) Neuropil was partially damaged and major dense lines of myelin sheath were separated; (3) Synaptic connections decreased; (4) Interstitium was swollen;(5) The numerical density of mitochondria in the experiment group was decrease,but the volume density showed no significant change. Conclusion: Mifespristone could cause ischemia-hypoxia changes in cerebrum of pregnant rats.