猪外周血淋巴细胞与心肌细胞β受体密度的相关性及其意义

β-AR density relativity of porcine myocardial tissue and circulating lymphocytes and its significance

目的 定量检测猪外周血淋巴细胞与心肌细胞膜上 β AR密度 ,研究其相关性并探讨其临床意义。方法 利用待屠宰的生猪 (7月龄 )共 48头 ,取少许左心室肌组织及外周血 ,用放射性同位素的方法测定其 β AR密度。 结果 外周血淋巴细胞与心肌细胞膜 β AR密度之间的散点图呈直线状分布 ;它们之间的相关系数为 :r =0 845 ,P <0 0 0 1;其直线回归方程为 :y =0 0 0 2 5 2 7X +0 72 6。结论 猪外周血淋巴细胞与心肌细胞膜上 β AR密度具有明显的正相关性 ,故对外周血淋巴细胞膜 β AR密度的检测可反映其心肌细胞膜上 β AR密度的变化。结果提示 :可用外周血淋巴细胞膜 β AR密度的检测来监测本身或药物所诱导的心肌细胞膜上 β AR密度的变化。

Objective To study β AR density relativity between porcine myocardial tissue and circulating lymphocytes and clinical significance .Methods 48 porcines(seven months old),were taken a few of myocardial tissue and peripheral blood.Assay β AR density with radioactive isotope to study the relativity.Results Scatter plot of β AR density circulating lymphocytes and myocardial tissue showed linear Correlation(r=0 845,P<0 001 Y=0 002527X+0 726).Conclusion There was obvious correlation on β AR density in circulating lymphocytes and myocardial membrane of pigs.Determination of β AR density in circulating lymphocytes can reflect alteration of that in myocardial tissue.Therefore,we can use it to monitor and investigate self induced and drug induced β AR changes.