肥胖对高血压病人胰岛素抵抗的影响

Effects of obesity on insulin resistance in patients with hypertension

目的 观察肥胖是否加重高血压病人的胰岛素抵抗。方法 患者口服 75 g葡萄糖作口服葡萄糖耐量实验 (OGTT)和胰岛素释放实验 ,用已糖激酶法测血糖 ,放免法测胰岛素和C肽 ,并以单纯高血压、单纯肥胖及健康者作对照进行分析。结果 高血压肥胖、单纯肥胖及单纯高血压者有高胰岛素血症和胰岛素抵抗 ,尤以肥胖高血压者最为明显 ,且与单纯肥胖者比较 ,胰岛素释放高峰延迟。结论 高血压肥胖者存在高胰岛素血症和胰岛素抵抗 。

Objectives To observe whether obesity aggravate insulin resistance in essential hypertensive patients.Methods Oral glucose tolerance test(OGTT)and insulin release test was used to investigate the presence of insulin resis tance.Serum glucose was measured by hexokinase assay and serum insulin and C-peptide was measured by radioimmunoassay.Results The results showed that the patients with hypertension and simple obesity had significantly high levels of plasma glucose and insulin than those of normal group,especially in those patients with hypertension obesity,the peak of curve in their tests appear later than that in the simple obesity. Conclusions The patients with essential hypertensive obesity might have insulin resistance and hyperinsulinemid.The obesity may aggravates insulin resistancein essential hypertensive patients.