米非司酮预治疗后以米索前列醇中止妊娠给药途径探讨

The studies of two ways in 10～16 weeks pregnancy with mifepristone and mosoprostol

目的 观察米非司酮 10 0mg预治疗后米索前列醇 (简称米索 )对中止 10～ 16周妊娠二种给药途径的有效性及安全性。方法 选择妊娠 10～ 16周无任何米非司酮及米索禁忌症要求中止妊娠的病例 86例 ,经口服米非司酮 5 0mg (服药前后 2小时禁食水 ) ,12小时一次共 10 0mg后 ,随机分为试验组肛门 (直肠内 )放置米索 ,对照组阴道放置米索。末次米非司酮用药 1 5～ 2小时后 ,实验组、对照组各放置米索 10 0 μg ,每 3～ 4小时一次至宫缩规律后停药。结果 实验组有效率 10 0 % ,完全流产率 84 0 % ,对照组有效率 10 0 % ,完全流产率83 3% ,流产后阴道流血量及月经复潮经量与平时月经量大多数相似 ,肛门 (直肠 )用药更能减少感染机会。结论 米非司酮预治后米索用于 10～ 16周妊娠引产安全、有效、简便、痛苦轻、损伤小 ,肛门 (直肠 )

Objective To study affect and safety of two ways to end 10～16 weeks pregnancy with mifepristone and misoprostol. Methods 86 cases pregnant for 10～16 weeks were designed randomly to two groups after 12 hour administration of mifepristone 100mg. Test group was placed misoprostol 100μg/3～4 hour in anus until uterus regular contraction. The control group was placed soprostol 100ug/3～4 hour in vagina until uterus regular contraction. Results Effective rate of test group is 100%, total abortion rate is 84 0%. Effective rate of control group is 100%, total abortion rate is 83 3%. The amount of bleed is similar to the amount of menstruation. The way in anus reduce the infection rate even more. Conclusion The way in ending 10～16 weeks pregnancy with mifepristione and misoprostol is safly effective and simple. The way in anus is prior to the way in vagina.