血管内皮生长因子诊断和监测卵巢恶性肿瘤的临床研究

Study on clinical application of vascular endothelial growth factor in diagnosis and monitoring of ovarian malignant tumour

目的 探讨血管内皮生长因子 (VEGF)对卵巢恶性肿瘤的诊断和病情监测作用。方法 收集卵巢肿瘤 6 5例为研究对象 ,采用酶联免疫法动态检测血清VEGF水平 ,内胚窦瘤病例同时放免测定血清甲胎蛋白(AFP)水平。结果 ①卵巢恶性肿瘤术前血清VEGF水平明显高于卵巢良性肿瘤和健康妇女 ,晚期病例明显高于早期病例 ,均有极显著差异。②血清VEGF与AFP水平均随卵巢恶性肿瘤病情控制而变化 ,且两者呈高度正相关。动态监测血清VEGF水平诊断卵巢恶性肿瘤及其分期和预后的准确性均在 80 %以上。结论 血清VEGF水平与卵巢恶性肿瘤的生长、转移和预后有密切关系 ,具有肿瘤标志物特性 。

Objective To study the roles of vascular endothelial growth factor(VEGF) on the diagnosis and monitoring of ovarian malignant tumour.Methods 65 ovarian neoplasms were collected.Serum VEGF levels were continuously determined by enzymoimmunoassay before and after operation,serum AFP in patients with endodermal sinus malignant tumour were monitored by radioimmunoassay.Results ①Serum VEGF levels before operation in patients with ovarian malignant tumour were significantly higher than those with benigh ones and the healthy controls.Serum VEGF levels in patients with advanced stage ovarian malignant tumour were apparently higher than those at early stage.②Serum VEGF levels had a positive correlation with the AFP levels,and they progressively dropped under the control of illness.Serum VEGF levels could be used to diagnose ovarian malignant tumour,determine their stages and outcomes with an accuracy of 80% by dynamic monitoring.Conclusion Serum VEGF with the characteristics of tumor markers shows a strong relationship with growths,metastases,outcomes of ovarian malignant tumour.So it can be one of the parameters of diagnosis and illness monitoring in ovarian malignant tumour.