烯萜醇对大鼠胃腺癌的作用

Effect of Xi Tie Alcohol on Adenocarcinoma of Stomach in Rats

目的观察烯萜醇对大鼠胃腺癌的治疗作用.方法经饮水摄入N-甲基-N'-亚硝基-N-亚硝基胍(MN-NG,150mg/L)诱发大鼠胃腺癌,同时食烯萜醇添加食进行治疗.结果食烯萜醇添加食20 g/Kg,10g/kg,32周大鼠胃腺发生原位癌、浸润癌,胃癌发生率分别为11.5%,22.6%,平均癌巢数分别为0.12±0.58,0.8±0.75,与对照组比较具有显著差异(P＜0.01或P＜0.05),且与给药剂量密切相关.结论烯萜醇具有抑制大鼠胃腺癌的作用.

Objective The experiment is to observe the effect of Xi Tie alcohol on adenocarcinoma of stomach in rats.Methods MNNG 150mg/L was taken in through drinking water to induce adenocarcinoma of stomach in rats.At the same time,the rats were added food with Xi Tie alcohol.Results With Xi Tie alcohol 20g/kg,10g/kg was taken in, and in 32 weeks the incidence of carcinoma in situ,infiltrative carcinoma and carcinoma of stomach in the gastric glands of rats were 11.5% and 22.6% respectively,the number of cancer nests in average was 0.12±0.58 and 0.80±0.75 respectively,and showed significant difference with the control group(P<0.01 or P<0.05),also closely correlated with the dose of drug administration.Conclusion Xi Tie Alcohol exhibit the effect of inhibiting adenocarcinoma of stomach in rats.