利心煎剂对麻醉大鼠冠脉结扎再灌注VF发生率的影响

Effect of Lixin Decoction on the Incidence of Lethal VF Induced by the Coronary Artery Ligation-reperfusion in Anesthetized Rats

目的观察利心煎剂对麻醉大白鼠冠脉结扎-再灌注引起的致死性心室纤颤(VF)发生率的影响.方法麻醉大鼠十二指肠直接给药(20 mL/kg)1 h后结扎冠脉,5 min后放开结扎再灌注,记录Ⅰ导电图,观察致死性VF的发生率.结果利心煎剂与对照组比较能显著降低致死性VF的发生率(对照组为80%,给药组为30%).结论利心煎剂可用于预防缺血性心脏病猝死.

Objective To examine the effect of Lixin decoction on the lethal VF induced by the coronary artery ligation-reperfusion in anesthetized rats.Methods One hour after the administration of Lixin decoction (20ml/kg)to the duodenum of the anesthetized rats,the rat coronary ligation-reperfusion was performed after 5 minutes and the leadⅠ ECG was recorded,the incidences of lethal VF were examined.Results Lixin decoction decreased the incidences of lethal VF significantly (80% in control group,30% in drug treated group).Conclusion Lixin decoction can be used to prevent the sudden death in the ischemic heart diseases.