急性心肌梗塞患者血浆ET和PⅢNP变化及其临床意义

Clinical Significance of Changes of Plasma ET and PⅢNP Levels in Patients with Acute Myocardial Infarction (AMI)

目的 :探讨血浆内皮素 (ET)和Ⅲ型胶原氨基端肽 (PⅢNP)水平与急性心肌梗塞患者病情变化的关系。方法 :采用放射免疫分析法 (RIA)随访了 32例AMI患者 ,并在各时相间比较。结果 :AMI在入院正规治疗后 ,ET于 8小时组达其血浆峰值 ,与正常对照比较P <0 .0 0 1。 7天组与 14天组比较无变化 (P >0 .0 5 ) ,但仍高于正常水平 (P <0 .0 1)。PⅢNP有类似于ET的相关变化 ,但于 48小时组达其血浆峰值。结论 :ET与PⅢNP参与了AMI的病情演变过程 ,并发挥重要作用 ;持续血浆高水平可能与心肌硬化、梗塞的形成和复发有关。这为临床应用ET受体拮抗剂提供了一点依据。

Objective To study the changes of plasma ET and PⅢNP levels during the recovery process of AMI patients. Methods Plasma ET and PⅢNP levels were mesured in different time phase with RIA after the starting regular theraphy. Results Compared with the control group, ET levels reached peak at 8h ( P <0.001) and remaining high at 7th day and 14th day ( P <0.01). PⅢNP values were of similar changes but reached its peak at 48h. Conclusion ET and PⅢNP might play an importent role in AMI patient's recovery process. Consistent high plasma levels might account for myocardial sclerosis and AMI recurrency, thus, giving certain antagonists were advisable in AMI pattient's therapy regime.