多发性脑梗死性痴呆及脑梗死患者血清载脂蛋白E测定及意义

Serum apolipoprotein E levels in patients with multi-infarct dementia and cerebral infarction

目的 检测多发性脑梗死性痴呆 (MID)及脑梗死 (CI)患者血清载脂蛋白E(ApoE)含量 ,探讨ApoE测定的临床意义。 方法 选取 2 0例MID患者、2 4例CI患者及 2 4例正常对照者 ,分别运用单克隆抗体ELISA法测定血清ApoE含量 ,同时测定血清TC、TG、HDL C、LDL C、ApoA和ApoB含量 ,并进行相关分析。结果 与对照组比较 ,MID和CI患者血清ApoE、ApoB及LDL C含量显著升高 (P <0 .0 5 ) ,HDL C和ApoA含量显著降低 (P <0 .0 1) ,TC及TG含量升高 ,但无统计学意义 (P >0 .0 5 )。结论 MID和CI患者均有脂代谢异常 。

Objective To investigate possible apolipoprotein E(ApoE) role in the pathogenesis of multi infarct dementia(MID) and cerebral infarction(CI). Methods We measured serum ApoE, TC, TG, HDL C, LDL C, ApoA, ApoB levels in 20 cases of MID, 24 cases of CI and 24 sex and age match control subjects by monoclonal anti enzyme linked immunosorbent assay (McAb ELISA). Results Higher serum ApoE levels was found in MID and CI groups ( P < 0.01 ), but no difference between them ( P > 0.05 ). A positive association of ApoE levels with TC,LDL C,ApoB in MID and CI groups, and a negative one with HDL C ( P < 0.01 ). Conclusion This data indicate that ApoE plays an important role in the pathogenesis of MID and CI, serum ApoE could be used as a key index in abnormol lipid metabolism, and its sensitivity and specificity is superior to the other regular lab indexes.