摘要
目的 :探讨鼻腔 T/ NK细胞非霍奇金淋巴瘤 (non- Hodgkin′s lymphoma,NHL )的发病、诊断及预后。方法 :对 2 0例 T/ NK细胞淋巴瘤的临床诊断及治疗结果进行回顾性分析。结果 :本组病例占我院同期收治 380例淋巴瘤的 5 .3% ,男 15例 ,女 5例 ,年龄 12～ 75岁。临床症状以鼻阻、涕血为主 ,多伴发热、疼痛。表现为鼻腔占位性病变及邻近软组织广泛受侵、骨破坏及溃疡 ,中线部位的破坏是其突出的面部特征 ;7例伴同侧颈淋巴结肿大 (35 .0 % )。本组病例均经病理确诊 ,病理类型均属 T/ NK- NHL。 16例患者采用化疗加放疗为主的综合治疗 ,平均随访 19.3个月。结论 :鼻腔 T/ NK- NHL治疗效果差 ,预后不良 ,临床易误诊 ,综合治疗宜早期进行。
The clinical feature, diagnosis, treatment and prognosis of primary nasal cavity T/NK cell non\|Hodgkin′s lymphoma (NHL) were retrospectively analyzed. Twenty patients with T/NK cell\|NHL in nasal cavity were treated from October 1994 to November 2000. There were 15 males and 5 females, ranging in age from 12 to 75 years old. The clinical symptoms were often with rhinostegnosis and rhinorragia (80.0%), fever and headache (55.0%). Those tumors showed extensive soft tissue invasion, necrosis and ulceration. The destruction of the midline area was the important face feature. Among 20 cases, enlargement of the cervical lymph node was 7 cases (35.0%). The pathological diagnosis and immunohistochemical tests were performed in 20 cases and 13 cases respectively. The enough combine of the chemotherapy and radiotherapy were performed in 16 cases, chemotherapy alone in 2 cases, radiotherapy alone in 1 case, and support therapy in 1 case. Results of pathological diagnosis and immunohistochemical tests confirmed that the pathological type was T/NK cell\|NHL in all 20 patients. The effects of therapy showed that the PD was 4 cases (died in 2 months), PR was 4 cases, CR was 12 cases, which followed\|up 19 3 months. The prognosed of nasal cavity T/NK cell\|NHL was no satisfactory, easy to be misdignosed, and the combination therapy should be given as early as possible.
出处
《耳鼻咽喉（头颈外科）》
2001年第3期146-149,共4页
Chinese Arch Otolaryngology-Head Neck Surg
