摘要
目的 :检测睡眠呼吸暂停综合征 (SAS)患者血浆中NO水平 ,分析SAS患者睡眠时的呼吸暂停指数 (AI)、平均血氧饱和度 (SpO2 )与NO水平的关系。探讨SAS患者体内NO水平变化的可能原因及对机体的影响。方法 :应用硝酸还原酶法测定血浆NO水平。用澳大利亚产Autoset和多导睡眠仪 (PSG)检测SAS患者AI、SpO2 。结果 :SAS患者血浆NO水平与正常组比较显著增高 (男性P <0 .0 0 1 ,女性P <0 .0 1 )。NO含量与AI无相关性 (r=0 .0 63) ,与SpO2 呈负相关 (r=- 0 .61 8)。结论 :SAS血浆NO水平升高可能与患者呼吸系统炎症有关。
Objective:To explore the change of NO level in SAS and its effect on the organisms,the plasma NO level in patient with SAS was measured and the relation between apnea index(AI) and SpO 2 and NO level was analysed.Method:The plasma NO level was determined by nitrate reductase,the AI and SpO 2 of patients were detected by Autoset and polysomnography(PSG) systems.Results:The plasma NO level in SAS group was higher than that in normal group.The NO content has no relation with AI(r=0 063),and has negative relation with SpO 2(r=-0 618).Conclusion:The elevation of plasma NO in SAS is relevant on inflammation of respiratory system.
