血清可溶性血管细胞黏附分子-1浓度与胃癌的关系

Relation between serum concentration of soluble vascular cell adhesion molecule-1 and gastric cancer

目的 :研究血清可溶性血管细胞黏附分子 (sVCAM 1)的含量与胃癌关系。方法 :用酶联免疫吸附试验分别测定 2 5例正常人、30例术前未作任何治疗及术后 1周无感染的胃癌病人血清sVCAM 1的浓度 ,研究其浓度与胃癌的临床、病理的关系。结果 :胃癌组血清sVCAM 1比胃溃疡组及正常对照组明显增高 (P <0 .0 0 1) ;术后血清sVCAM 1浓度显著下降(P <0 .0 0 1)。结论 :sVCAM 1有望成为胃癌的早期诊断及是否复发的指标。

Objective:To study the relation between serum concentration of soluble vascular cell adhesion molecule 1(sVCAM 1) and gastric cancer. Methods:A technique of enzyme linked immunosorbent assay was used to determine serum concentration of sVCAM 1 in 25 healthy people,30 patients with gastric cancer without treatment before operation and without infection one week after operation. The relation between concentration of sVCAM 1 and the clinical and pathological changes of gastric cancer was studied. Results:Serum concentration of sVCAM 1 in patients with gastric cancer was much higher than that in patients with gastric ulcer or in healthy people( P <0.001). The postoperative serum concentration of sVCAM 1 significantly decreased( P <0.001). Conclusion:Serum concentration of sVCAM 1 is expected to be an index in early diagnosis and recurrence of gastric cancer. [