城市和农村急性血吸虫病病人临床治疗的比较研究

STUDY ON COMPARISON OF CLINICAL MANIFESTATIONS AND TREATMENT OF PATIENTS OF ACUTE SCHISTOSOMIASIS IN URBAN AND RURAL AREAS

目的 研究城市和农村急性血吸虫病病人的临床表现及对化疗的不同反应。 方法 将 1995年住院的急性血吸虫病病人分成城市和农村两个观察组 ,比较两个组患者的临床症状和吡喹酮对体温的影响。 结果 两组患者被误诊天数的差异无显著性 ,无论在城市和还是在农村 ,误诊都很普遍 ;除发热外 ,急性血吸虫病病人最主要的临床表现为畏寒、咳嗽、腹痛、腹泻等 ,城市病人诉说的症状更多 ,更不集中 ;急性感染对两组病人的肝功能影响很小 ;城市组儿童单疗程治疗后体温降至正常的天数显著短于农村组 ,而双疗程组儿童 ,城市组明显长于农村组 ,成人组之间差异均无显著性。结论 城乡医院对急性血吸虫病的误诊均相当普遍 ;城乡两组病人对吡喹酮的临床反应基本无差异 ;临床使用双疗程吡喹酮治疗急性感染是合理和可行的。

Objective To study the clinical manifestations and responses to drug therapy of patients of acute schistosomiasis in urban and rural areas. Methods The acute schistosomiasis patients hospitalized in 1994 were divided into 2 groups, ie urban group and rural group, and two groups were compared in terms of clinical manifestations and the influence of praziquentel on body temperature. Results There is no significant difference in the misdiagnosed days between the two groups, and misdiagnosis is quiet common in both urban and rural areas; Acute schistosomiasis patients manifested chill, cough, abdominal pain,more and disperse symptoms; No affect was found in hepatic functions of patients of two groups; Days for body temperature recovering to normal after single treatment course were shorter in urban children patients than in rural ones, but after 2 treatment courses, the days were longer in urban patients than in rural children. No difference was found in days between adults of urban and rural areas. Conclusion Misdiagnosis is quiet common and there is no significant difference in the effects of patients forward praziquentel between 2 groups. Two-course treatment with praziquentel is rational and practical for acute schistosomiasis.