心磷脂抗体与缺血性脑血管病

Analysis Anti-cardiolipin Antibodies in Ischemic Cerebrovascular Diseases

目的 建立测定血清心磷脂抗体 (A-CL)的方法 ,研究 A-CL与缺血性脑血管病的关系。方法 建立心磷脂抗体的 ELISA检测方法 ,对 4 2例健康者和 85例缺血性脑血管病、其他神经系统疾病患者血清 A-CL(Ig G、Ig M)进行测定。结果 51例缺血性脑血管病中 ,1 1例 A-CL Ig G阳性 ,5例 A-CL Ig M阳性 ,脑出血及其他神经系统疾病均为阴性。

Objective By determining serum cardiolipin antibodies(A CL) to explore the relation of autoantibody and ischemic cerebrovascular diseases.Methods Serum A CL(IgG,IgM) were determined by (ELISA),85 patient sera with ischemic cerebrovascular disease, cerebrovascular hemorrhages, GBS, Hallervorden spatz were evaluated and comparied with 42 normal peoples. Results In 51 ischemic cerebrovascular disease patients,11 patients were A CL IgG positive, and 5 patients showed A CL IgM positive. All of cerebrovascular bleeding and other neurologic disease patients was A CL negative.Conclusions Serum A CL were strongly related to ischemic cerebrovascular disease . This results suggests that A CL may be a associated factor of ischemic cerebrovascular disease.